Evidence for Hydroxocobalamin in Cyanide Toxicity Caused by Smoke Inhalation: An Updated Systematic Review.

ABSTRACT:

Background

Hydroxocobalamin is the first-line treatment for confirmed cyanide poisoning. Its empiric use in patients with smoke inhalation injury-where cyanide toxicity is often suspected but not confirmed-remains controversial. Further research is needed to fully understand the benefits and risks associated with its use. This study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines to provide a systematic review of the use of hydroxocobalamin for the treatment of cyanide poisoning secondary to smoke inhalation injury, with a particular focus on mortality and adverse reactions.

Methods

A systematic search of the Cochrane Library, PubMed, and Embase was conducted for studies on cyanide poisoning from smo

SUBMITTER: Jin WY 

PROVIDER: S-EPMC12767669 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature