Atrazine use and markers of kidney function and nephrotoxicity among male farmers in the Biomarkers of Exposure and Effect in Agriculture Study.

ABSTRACT:

Objective

Atrazine, an herbicide widely used in US agriculture, has been associated with kidney cancer and non-malignant kidney disease. However, the potential mechanisms underlying these associations remain unclear. We evaluated atrazine use and biomarkers of kidney function and nephrotoxicity among male farmers in the Biomarkers of Exposure and Effect in Agriculture Study.

Methods

Our investigation included three groups of farmers defined based on atrazine use: (1) both recent (last 3 months) and past use (continuous users; n=83); (2) high lifetime use (≥178.5 lifetime days) but no recent use (former high users; n=88) and (3) never/low lifetime use (<50 lifetime days) and no recent use (never/low users; n=75). Biomarkers were measured in serum (creatinine, cystatin C, urea

SUBMITTER: Andreotti G 

PROVIDER: S-EPMC12767703 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature