Mechanochemistry Enables Rapid and Solvent-Free Wittig Reactions on Sugars.

ABSTRACT: A versatile solvent-free Wittig olefination of sugars via mechanochemistry is reported, tolerating common protecting groups as well as unprotected substrates. The method efficiently delivers structurally diverse olefins under mild and solvent-free conditions. Subsequent solvent-free late-stage modifications of the olefins demonstrate the potential of the methodology for greener sugar-based synthetic sequences.

SUBMITTER: Mele F 

PROVIDER: S-EPMC12767755 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature