DNA-Loaded Nanoparticles Reprogram the Tumor Immune Microenvironment to Treat Brain Tumors.

ABSTRACT: Despite advances in treatment and therapeutic strategies, patients with brain tumors, including glioblastoma (GBM) and meningioma, still face high rates of recurrence, morbidity, and mortality. Nonviral biodegradable nanoparticles are advanced materials with the potential to reprogram brain tumor cells and the tumor immune microenvironment. Localized delivery of poly(beta-amino ester) nanoparticles encapsulating immunostimulatory genes is utilized to reprogram brain tumor cells into tumor-associated antigen-presenting cells (tAPCs) by inducing overexpression of costimulatory 4-1BBL on the surface of brain tumor cells and IL-12 secreted into the tumor microenvironment. In both a humanized mouse model using human meningioma (IOMM-Lee) and an immunocompetent syngeneic orthotopic model using m

SUBMITTER: Yang J 

PROVIDER: S-EPMC12767759 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature