Key role for inhibins in effective T cell activation, migration and Th17 differentiation.

ABSTRACT: Our group has previously reported that inhibin and its molecular pair, TGF-β type III receptor (TβRIII), regulate T cell development within the thymus. In addition, inhibins play a key role in immune tolerance through the modulation of dendritic cell (DC) maturation and peripheral Treg induction. However, the functional role of inhibins in T cell activation and differentiation is currently unknown. Here, we demonstrate that inhibins are produced by activated T cells and play a role during T cell activation, migration, and functional Th differentiation. Specifically, stimulation of Inhα^-/- naïve T cells resulted in decreased expression of early activation markers, including CD69, CD25, and TβRIII, compared to Inhα^+/+ T cells. Additionally, we analyzed the migratory pot

SUBMITTER: Ortega-Francisco S 

PROVIDER: S-EPMC12767762 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature