Tryptophan metabolite atlas uncovers organ, age, and sex-specific variations.

ABSTRACT: Tryptophan (Trp) is the largest and most structurally complex amino acid, yet it is the least abundant in the proteome. Its distinct indole ring and high carbon content allow it to give rise to several biologically active metabolites, including serotonin, kynurenine (Kyn), and indole-3-pyruvate (I3P). Dysregulation of Trp metabolism has been implicated in a range of diseases, from depression to cancer. Investigating Trp and its metabolites in healthy tissues provides insight into how disease-associated disruptions may be targeted selectively while preserving essential physiological functions. Whereas previous studies have typically focused on individual organs or single metabolic branches, our analysis spans 12 peripheral organs, the central nervous system, and serum in male and female (C5

SUBMITTER: Perez-Castro L 

PROVIDER: S-EPMC12767773 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature