Freeze-microwave vacuum drying optimizes structure and dual antidiabetic activities of <i>Pyracantha fortuneana</i> fruit polysaccharides.

ABSTRACT: Drying regimes strongly shape fruit-polysaccharide structure and antidiabetic function, yet their structure-function consequences in Pyracantha fortuneana remain unclear. Six scalable methods-natural (ND), hot-air (HD), infrared (IRD), freeze-drying (FD), microwave-vacuum (MVD), and freeze-microwave-vacuum drying (FMVD)-were therefore compared for their effects on P. fortuneana fruit polysaccharides (PFPs). FMVD produced the highest polysaccharide yield (6.22 %) and uronic acid content (45.48 %), while lowering weight-average molecular weight from 740.47 to 134.08 kDa relative to ND and generating low-crystallinity, thermally stable polymers. These structural advantages translated into superior bioactivity: PFP-FMVD showed the strongest α-glucosidase inhibition with an IC

SUBMITTER: Sun J 

PROVIDER: S-EPMC12767801 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature