Nanoparticles coated with osteoblast-like cell membranes as curcumin delivery vehicles for targeted postmenopausal osteoporosis therapy.

ABSTRACT: Postmenopausal osteoporosis, driven by estrogen-deficient bone loss, faces therapeutic challenges due to current drug side effects and off-target effects. While curcumin demonstrates dual osteogenic and antiresorptive activity, its clinical translation is hindered by poor aqueous solubility, chemical instability, and photolability. A bone-targeted delivery system using osteoblast-like cell membrane-coated nanoparticles was designed to enhance precision and efficacy for treating osteoporosis. Through systematic database analysis, osteoblast-like cell membrane containing CXCR4 and TNF-α receptors were selected to coat curcumin-loaded PLGA nanoparticles (Cur@NPs), namely OM/Cur@NPs. OM/Cur@NPs and Cur@NPs were injected into ovariectomized (OVX) mice to comparatively assess in vivo bone

SUBMITTER: Li Q 

PROVIDER: S-EPMC12767803 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature