Sodium butyrate ameliorates lipid metabolism disorder, intestinal injury, and microbial dysbiosis in broilers under lipopolysaccharide-induced immune stress condition.

ABSTRACT: Immune stress is a major challenge in the poultry industry, impairing growth, liver metabolism, and intestinal health. This study investigated whether dietary sodium butyrate (NaBu) could alleviate lipopolysaccharide (LPS)-induced immune stress in yellow-feathered broilers through modulation of the gut-liver axis. A total of 96 male broilers were assigned to a 2 × 2 factorial design with NaBu supplementation and LPS challenge as the main factors. Results showed that NaBu significantly improved growth performance, as reflected by increased average daily gain and average daily feed intake (P < 0.05). NaBu also markedly optimized serum lipid metabolism by decreasing total cholesterol (P < 0.05), and LDL-C (P < 0.05), while increasing HDL-C (P < 0.05). Moreover, NaBu significantly alleviated h

SUBMITTER: Wang L 

PROVIDER: S-EPMC12767853 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature