Evolutionary, structural and functional relationships revealed by comparative analysis of syntenic genes in Rhizobiales.

ABSTRACT:

Background

Comparative genomics has provided valuable insights into the nature of gene sequence variation and chromosomal organization of closely related bacterial species. However, questions about the biological significance of gene order conservation, or synteny, remain open. Moreover, few comprehensive studies have been reported for rhizobial genomes.

Results

We analyzed the genomic sequences of four fast growing Rhizobiales (Sinorhizobium meliloti, Agrobacterium tumefaciens, Mesorhizobium loti and Brucella melitensis). We made a comprehensive gene classification to define chromosomal orthologs, genes with homologs in other replicons such as plasmids, and those which were species-specific. About two thousand genes were predicted to be orthologs in each chromosome and abou

SUBMITTER: Guerrero G 

PROVIDER: S-EPMC1276791 | biostudies-literature | 2005 Oct

REPOSITORIES: biostudies-literature