Low-concentration contrast abdominopelvic CT: A comparison with high-concentration contrast CT image quality.

ABSTRACT:

Objective

This study aimed to compare abdominopelvic computed tomography (APCT) image quality using low and high concentrations of a contrast agent in patients with cancer via a noninferiority design.

Methods

This study prospectively included 99 patients with malignancies who underwent dual-source APCT following injection of 1.5 mL/kg of iohexol 270 (low-concentration group). The control group included patients who were retrospectively matched 1:1 based on weight, body mass index, and sex. These patients (high-concentration group) received 1.1 or 1.2 mL/kg of iohexol 350, reconstructed at two tube voltages (80 kVp and 80/Sn150 kVp). The noninferiority margins were set at -0.21 for overall image quality. Two radiologists blindly and independently analyzed the subjective and o

SUBMITTER: Yoon S 

PROVIDER: S-EPMC12768260 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature