Activation and DNA methylation of PANoptosis in polycystic ovary syndrome.

ABSTRACT:

Background

Polycystic ovarian syndrome (PCOS) is a reproductive endocrine disorder involving various pathophysiological factors and is currently incurable. This study aimed to explore the potential role of pan-apoptosis in PCOS.

Methods

Differentially expressed genes (DEGs) between PCOS and healthy controls were identified in GSE155489 and GSE10946, and enrichment analysis was performed. The activation of PANoptosis in PCOS was evaluated, PANoptosis-related DEGs were screened, and the receiver operating characteristic (ROC) curve was plotted. The methylation modification of PANoptosis-related DEGs were assessed from differentially methylated probes in GSE80468 dataset. Protein expression was detected using Western blot, and DNA methylation levels were measured using PCR in P

SUBMITTER: Han Y 

PROVIDER: S-EPMC12768346 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature