Evaluating the role of graft angle on cerebral hemodynamics following direct cerebral bypass for moyamoya disease.

ABSTRACT: Direct cerebral bypass is a key treatment for moyamoya disease (MMD). This surgery grafts a donor vessel onto a recipient cerebral artery to boost blood flow to hypoperfused brain regions. Unlike coronary bypass, which restores downstream flow around a blockage, cerebral bypass for MMD reverses flow in the recipient vessel to perfuse the upstream network. Surgical decisions-such as donor vessel choice and anastomosis angle-significantly affect graft hemodynamics and outcomes. Yet these choices still rely on neurosurgeons' experience, lacking quantitative guidance. This study addresses that gap by examining how anastomosis angle shapes post-surgical perfusion and wall shear stress. We created idealized cerebral bypass models with graft angles of 30°, 60°, and 90°. Each model's flow field wa

SUBMITTER: Peng C 

PROVIDER: S-EPMC12768355 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature