Ureaplasma-driven inhibition of the epithelial Na+ transport in fetal alveolar cells: A novel mechanism of Ureaplasma-mediated preterm lung disease.

ABSTRACT: Respiratory tract colonization with Ureaplasma species has been repeatedly associated with the development of acute and long-term pulmonary morbidity in preterm infants. However, despite strong evidence from observational studies and animal models, apart from inflammation, underlying mechanisms of Ureaplasma-driven lung disease, such as potential functional impairments, are mainly unknown. Knowledge of Ureaplasma-lung interaction and Ureaplasma virulence factors is scarce. The present investigation is the first to examine the influence of perinatal Ureaplasma infection on critical mechanisms of alveolar fluid clearance (AFC) in immature lung cells, which drive perinatal transition from fluid-filled lungs before birth to alveolar fluid absorption, enabling lung breathing. Disruption or impa

SUBMITTER: Glaser K 

PROVIDER: S-EPMC12768415 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature