Associations of Testosterone and Related Hormones With All-Cause and Cardiovascular Mortality and Incident Cardiovascular Disease in Men : Individual Participant Data Meta-analyses.

ABSTRACT:

Background

Whether circulating sex hormones modulate mortality and cardiovascular disease (CVD) risk in aging men is controversial.

Purpose

To clarify associations of sex hormones with these outcomes.

Data sources

Systematic literature review to July 2019, with bridge searches to March 2024.

Study selection

Prospective cohort studies of community-dwelling men with sex steroids measured using mass spectrometry and at least 5 years of follow-up.

Data extraction

Independent variables were testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone (DHT), and estradiol concentrations. Primary outcomes were all-cause mortality, CVD death, and incident CVD events. Covariates included age, body mass index, marital status, al

SUBMITTER: Yeap BB 

PROVIDER: S-EPMC12768424 | biostudies-literature | 2024 Jun

REPOSITORIES: biostudies-literature