Quantifying observable movement reserve in multiple sclerosis via upper diurnal activity quantiles.

ABSTRACT:

Background

The ability to sustain high-effort motor activity throughout the day may serve as a marker of functional capacity in individuals with multiple sclerosis (MS). We refer to this ability as observable movement reserve. Conventional assessments, including the Expanded Disability Status Scale (EDSS), often miss subtle functional changes. While accelerometry captures 24-hour motor activity, it typically overlooks peak activity and its diurnal variability.

Objective

To evaluate whether upper diurnal activity quantiles from accelerometry capture observable movement reserve and are associated with disability in MS.

Methods

In 248 adults with MS (mean age 54.8, 71% female, EDSS 0-6.5), wrist-worn accelerometry was recorded over 2 weeks. Scalar-on-function regression

SUBMITTER: Guha Niyogi P 

PROVIDER: S-EPMC12768448 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature