Spatial Ion Compression without Loss of Resolution on a Cyclic Ion Mobility Spectrometry-Mass Spectrometry Platform.

ABSTRACT: Traveling wave-based ion mobility spectrometry-mass spectrometry (IMS-MS) has emerged as an analytical technique, particularly because of technological improvements for enabling the scalable resolution of challenging biomolecules. However, IMS-MS remains limited by peak broadening from diffusion in extended separations, thus precluding further gains in sensitivity and resolution. Previous efforts have attempted to overcome these issues through the development of peak compression strategies, such as compression ratio ion mobility programming (CRIMP) and temporal compression. Unfortunately, both previous compression strategies suffer from certain drawbacks related to resolution. Herein, we present a new reinjection-based spatial ion compression strategy implemented on a commercially availabl

SUBMITTER: Robinson PE 

PROVIDER: S-EPMC12768463 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature