Left atrial mechanics in youth with chronic kidney disease and similarly aged healthy controls.

ABSTRACT:

Background

In adults with chronic kidney disease (CKD), abnormal left atrial reservoir strain (LASr) is an early, yet clinically significant, indicator of myocardial dysfunction. However, left atrial mechanics are understudied in youth with CKD. The objective of this study was to assess left atrial strain function in youth with CKD and similarly aged, healthy controls.

Methods

We performed a single-center, retrospective, observational study of persons aged 12-21 years with stage 3-4 CKD and healthy controls. Exclusion criteria included a history of a kidney or other solid organ transplant, congenital heart disease, and/or dialysis requirement < 3 months prior. We measured LAS (LASr, conduit, and contractile), E/e', E/A, left ventricular mass index (LVMI), and ejection fracti

SUBMITTER: Kula AJ 

PROVIDER: S-EPMC12768583 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature