Exercise maintains LEAP2 levels after weight loss in females with obesity.

ABSTRACT: Liver-expressed antimicrobial peptide 2 (LEAP2) is an anorexigenic hormone, but its long-term decrease after diet-induced weight loss may promote weight regain. This study examined whether exercise, glucagon-like peptide-1 receptor agonist (GLP-1RA) (liraglutide), or their combination prevents the post-diet decrease in LEAP2 during 1 year of weight-loss maintenance. LEAP2 plasma levels were measured in the fasting state and during 3-h standard liquid meal tests (600 kcal) in a randomized, double-blinded, placebo-controlled trial. 128 adults with obesity were included (BMI: 36.9 ± 2.9 kg/m²), 79 females and 49 males. Sex differences were evident at data inspection. In males, fasting LEAP2 decreased during the low-calorie diet (LCD) (p < 0.001), while in females, there was

SUBMITTER: Holt J 

PROVIDER: S-EPMC12768860 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature