Male survival disadvantage in pulmonary hypertension: independent of aetiology, age, disease severity, comorbidities and treatment.

ABSTRACT:

Background

Sex-based differences in morbidity and mortality in pulmonary hypertension (PH) are underexplored, yet understanding these differences is vital for improving clinical management. This study investigates the influence of sex on survival of patients with PH in dependency of various disease conditions.

Methods

The PVRI GoDeep meta-registry integrates data from international PH registries, of which we analysed 21,123 incident hemodynamically fully characterised patients with PH. Survival analyses employed Kaplan-Meier and Cox proportional hazards models, adjusted for confounders and subjected to sensitivity analyses.

Findings

Male patients consistently showed significantly higher mortality than females across the overall PH population (hazard ratio 1.36 [1.23,

SUBMITTER: Yogeswaran A 

PROVIDER: S-EPMC12768861 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature