Adverse Muscle Composition Is an Early Feature of Chronic Kidney Disease and Associates With Poor Function and Comorbidities.

ABSTRACT:

Rational & objective

Sarcopenia is linked to increased morbidity and mortality in chronic kidney disease (CKD), but its definition and assessment vary considerably across studies. This study evaluated the technical feasibility of magnetic resonance imaging (MRI)-based assessment of adverse muscle composition (AMC)-defined as low muscle volume and high fat infiltration-and its associations with comorbidity, functional performance, and risk for coronary heart disease (CHD) in CKD.

Study design

This is a cross-sectional and prospective study.

Settings & participants

Participants included 11 patients from a single-center hemodialysis (HD) cohort and 903 individuals with CKD from the UK Biobank, along with matched controls without CKD. For each participant, a personalized

SUBMITTER: Indurain A 

PROVIDER: S-EPMC12768902 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature