Mapping brain tumor microstructure: A multimodal study of diffusion MRI, intraoperative fluorescence, and neuropathology in navigated biopsies.

ABSTRACT: High-grade glioma characteristics such as heterogeneity and diffuse growth present a major diagnostic and therapeutic challenge, making accurate imaging essential for diagnosis and surgical planning. Diffusion MRI (dMRI) shows promise in tissue identification through a negative correlation between the dMRI apparent diffusion coefficient and tumor cellularity. Further, tissue disorganization due to tumor growth is correlated with decreased fractional anisotropy (FA) from diffusion tensor imaging (DTI). Q-space trajectory imaging (QTI) through free gradient waveform encoding during dMRI acquisition has been suggested as a framework for dMRI scalar map generation, enabling disentangled measures of shape, size, and orientation. We aimed to extend a clinically integrated workflow for optical gu

SUBMITTER: Klint E 

PROVIDER: S-EPMC12768948 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature