Striatal (a-)symmetry reveals sex-specific autonomic vulnerabilities in early Parkinson's disease.

ABSTRACT: Autonomic symptoms are common in Parkinson's disease and vary according to patterns of dopaminergic neurodegeneration. The impact of sex and striatal denervation asymmetry are interesting avenues for observing distinct patient phenotypes from the early stages of the disease. This exploratory study investigates how striatal denervation asymmetry and sex influence autonomic dysfunction profiles in early-stage, treatment-naive Parkinson's disease. Using data from the Parkinson's Progression Markers Initiative (n = 759), we applied generalized linear mixed models to assess SCOPA-AUT scores across subtypes of striatal denervation (left-predominant, right-predominant, symmetric), modeling the interaction with sex. Patients with symmetric striatal denervation exhibited significantly greate

SUBMITTER: Nuber-Champier A 

PROVIDER: S-EPMC12768963 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature