Large-scale analysis of bacterial genomes reveals thousands of lytic phages.

ABSTRACT: Phages are typically classified as temperate, integrating into host genomes, or lytic, replicating and killing bacteria; for this reason, lytic phages are not expected in bacterial genome sequences. Here we analyse 3.6 million bacterial genome assemblies from 1,226 species and find 119,510 lytic phage genomes, which we term bacterial assembly-associated phage sequences. This represents a ~5-fold increase in the number of phages with associated hosts and raises questions about fundamental aspects of phage biology. Our analyses of bacterial assembly-associated phage sequences revealed previously undescribed phage clusters, including clusters distantly related to Salmonella Goslarviruses in Escherichia coli and Shigella, while also substantially expanding known genera such as Seoulvirus (from

SUBMITTER: Perfilyev A 

PROVIDER: S-EPMC12768965 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature