Gut microbiome-mediated transformation of dietary phytonutrients is associated with health outcomes.

ABSTRACT: Food, especially plant-based diet, has complex chemical diversity. However, large-scale phytonutrient-metabolizing activities of gut bacteria are largely unknown. Here we integrated and systematically analysed multiple databases containing information on enzymatic reactions and food health benefits, and 3,068 global public human microbiomes. Transformation of 775 phytonutrients from edible plants was associated with enzymes encoded by diverse gut microbes. In vitro assays validated the biotransformation activity of gut species, for example, Eubacterium ramulus. The biotransformation of phytonutrients demonstrated high interpersonal and geographical variability. Machine learning models based on 2,486 public case-control microbiomes, using the abundances of enzymes associated with modificati

SUBMITTER: Zhang L 

PROVIDER: S-EPMC12768975 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature