Hybrid genome sequence of Cryptococcus neoformans of Indian origin and comparative genome analysis.

ABSTRACT: Human opportunistic fungi C. neoformans are a global health concern as they cause severe pneumonia and cryptococcal meningitis in tropical and subtropical regions. Though the occurrence of infection has reduced from 2014 to 2022, the mortality rate remains high, and it is considered a neglected tropical disease. More studies are needed to elucidate the genomic architecture and functional traits required to underpin the disease management of Cryptococcus neoformans. This study showcases the first complete genome sequence of an Indian isolate of Cryptococcus, identified as subsp. grubii containing 4.8% of virulence genes in a total genome. A comparative virulome analysis revealed that study genomes Cn, H99 and JEC21 harbor crucial virulence genes associated with infection severity. While all

SUBMITTER: Sathiyamoorthy J 

PROVIDER: S-EPMC12769486 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature