Peripheral B cell alteration in patients with premature ovarian insufficiency.

ABSTRACT: Premature ovarian insufficiency (POI) is one of the most common diseases contributing to declining fertility globally. Autoimmune dysregulation has been implicated in POI, but the role of B cell and its subsets in immune dysregulation in POI remains unclear. In the current study, we investigated whether disturbances in the distribution and functional characteristics of peripheral B cell subsets are associated with POI and its severity. Our results revealed that POI patients exhibited a higher percentage of total CD19⁺ B cells, but the proportion of memory B cells (MBCs) and plasmablasts was significantly reduced compared to controls. A notable decrease in interleukin-10 (IL-10) production by B cells was observed, primarily due to a reduction in CD19⁺CD24^hiC

SUBMITTER: Lu Y 

PROVIDER: S-EPMC12769526 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature