Neutrophil extracellular traps associated with severity and prognosis of community-acquired pneumonia.

ABSTRACT: This study aimed to verify whether neutrophil extracellular traps (NETs) was related to the severity of respiratory tract infections (RTI) and establish a prognostic model for severe respiratory infections. Peripheral blood mononuclear cells (PBMC) were isolated from RTI patients for RNA sequencing. Weighted Graph Co-expression Network Analysis was performed to identify gene modules and analyze the correlation between gene modules and clinical features. The prognostic model was established by LASSO regression. The concentration of IL-8 in plasma was measured by Enzyme linked immunosorbent assay (ELISA). The gene expression levels in PBMC were detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR). In total, 120 patients with RTIs were enrolled between July 2022

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12769636 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature