Compiling an early life human gut microbiome atlas and identification of key microbial drivers.

ABSTRACT: During the first year after birth, the infant gut microbiome undergoes a rapid and profound compositional and functional transformation, impelled by an intricate network of intrinsic and extrinsic factors. This process results in increased taxonomic and functional diversification, alongside greater interindividual variability. To better understand this early-life ecosystem, this study assessed the interindividual variability of the infant gut microbiome using a comprehensive infant gut microbiome database of 5288 fecal metagenomic data from healthy, full-term infants across various geographical locations. Our study identified six reference microbial communities, termed Early-Life Community State Types (ELi-CSTs), which not only capture specific compositional profiles and heterogeneity of t

SUBMITTER: Tarracchini C 

PROVIDER: S-EPMC12769767 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature