Circulating Testican-2 and MGT5A are Markers of Membranous Nephropathy.

ABSTRACT:

Introduction

Membranous nephropathy (MN) is a common cause of nephrotic syndrome usually diagnosed using kidney biopsy.

Methods

We examined the association of 6592 plasma proteins with a diagnosis of MN in the Boston Kidney Biopsy Cohort (BKBC, n = 434), with replication of the top hits in the Nephrotic Syndrome Study Network (NEPTUNE, n = 132).

Results

In BKBC, 2 proteins, testican-2 and alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase (MGT5A), were associated with MN when compared with the reference diagnosis (normal or thin basement membrane [TBM] disease) as well as when compared with all other diagnoses among individuals who had undergone kidney biopsy for the indication of proteinuria or nephrotic syndrome. In NEPTUNE, plasma l

SUBMITTER: Kim T 

PROVIDER: S-EPMC12769794 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature