Search for novel biomarkers of febrile neutropenia in hematological patients: an overview.

ABSTRACT: A single-center prospective study was conducted at a tertiary care hospital in Kuopio Finland over the past two decades, searching for novel biomarker candidates to predict complicated course of febrile neutropenia (FN) in hematological patients. In Dec 2006‒Dec 2015, 85 patients with acute myeloid leukemia and 179 autologous hematopoietic stem cell transplant recipients were included. More than 20 biomarkers were evaluated in subsequent patient cohorts and compared to C-reactive protein (CRP) and procalcitonin (PCT). The samples were taken on d0-d2 from the beginning of FN. Here, we provide an overview of the results of these studies. Most biomarkers evaluated did not provide additional prognostic benefit compared to CRP or PCT. The most promising biomarkers warranting further studies inc

SUBMITTER: Jantunen E 

PROVIDER: S-EPMC12769988 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature