Breaking the Cycle of Preterm Birth: A Prospective Cohort Study on Maternal Stress and Recurrent Preterm Birth.

ABSTRACT:

Objective

To investigate the association between prenatal maternal perceived stress, salivary cortisol, and the odds of recurrent preterm birth (rPTB).

Design

Prospective cohort study.

Setting

Soroka University Medical Center and Clalit Health Maintenance Organization clinics in Israel.

Population

A total of 245 pregnant women with a history of spontaneous singleton PTB, all carrying singleton pregnancies in the current pregnancy. Data source were on-line self-completed computerised REDCap questionnaires and summary of computerised medical records including data on medications and laboratory results and cortisol in the saliva.

Methods

Participants provided saliva samples and completed stress questionnaires twice during pregnancy, with two assessments sep

SUBMITTER: Hagbi Bal M 

PROVIDER: S-EPMC12770073 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature