Free Fetal Haemoglobin in Severe Early-Onset Fetal Growth Restriction: A Prospective Multi-Centre Study.

ABSTRACT:

Objective

To assess fetal circulating free fetal haemoglobin (fHbF) levels and heme defences, correlated to fetal circulatory biometry and fetal sex in severe early-onset fetal growth restriction (FGR).

Design, setting and population

A prospective study severe early-onset fetal growth restriction pregnancies with close clinical management (estimated fetal weight (EFW) < 3rd centile and < 600 g at 20-26 + 6 weeks; N = 20).

Method & main outcome measures

Temporal fetal vascular obstetric biometry was recorded. Cord blood fHbF and key heme-scavenger defences were measured and compared with normal term births (N = 26) and births with late-onset FGR (N = 12).

Results

fHbF was elevated in early-onset FGR compared with normal pregnancy: 0.437(0.337/0.753) mg/mL; and 0

SUBMITTER: Brook A 

PROVIDER: S-EPMC12770088 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature