Antioxidants rescue murine mesangial cells from docosahexaenoic acid-induced ferroptosis.

ABSTRACT:

Background

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with anti-inflammatory effects. However, few studies have investigated their molecular effects in the kidney. We have previously shown that intrauterine growth restriction (IUGR) can lead to aggravation of mesangioproliferative glomerulonephritis and that n-3 PUFAs can attenuate long-term effects of IUGR by reversing pro-inflammatory molecular signatures in kidney cortex.

Results

The original aim of the study was to investigate the potential protective mechanisms of docosahexaenoic acid (DHA) on murine mesangial cells. However, stimulation with DHA alone led to reduced cell viability and ultimately cell death. Proteome analysis revealed significant regulation of ferroptosis-associated proteins. Increas

SUBMITTER: Saschin L 

PROVIDER: S-EPMC12770095 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature