Integration of microbiome and transcriptome information in helping diagnosis of colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a major global public health issue, with over 1.8 million new cases and 881,000 deaths in 2018. This study aims to explore the application of integrating microbiome and transcriptome analysis in the diagnosis of colorectal adenocarcinoma (COAD), focusing on its potential in identifying cancer biomarkers and predicting disease progression.

Methods

By utilizing COAD transcriptome and microbiome data from TCGA, diversity and differential expression analyses were conducted to identify microbiome composition differences between primary tumors (PT) and solid tissue normal (STN) samples, and the role of mRNA in prognosis. Mediation analysis was used to identify interactions between microbiome, transcriptome, in COAD tumors. The Multi-Omics Grap

SUBMITTER: He Z 

PROVIDER: S-EPMC12770112 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature