Identification of prognostic genes associated with mitochondria and macrophage polarization in prostate adenocarcinoma based on transcriptome and Mendelian randomization analysis.

ABSTRACT:

Background

Prostate adenocarcinoma (PRAD) is a common malignancy in the male genitourinary system, with growing evidence linking its progression to mitochondrial function and macrophage polarization. This study identifies prognostic genes associated with these factors in PRAD through integrated transcriptomic data analysis and Mendelian randomization (MR).

Methods

This study utilized transcriptome datasets from The Cancer Genome Atlas prostate adenocarcinoma (TCGA-PRAD). Candidate genes were selected by integrating mitochondrial-related genes (MRGs), macrophage polarization-related genes (MPRGs), and differentially expressed genes (DEGs). Prognostic genes were subsequently identified through MR and regression analyses, enabling the construction and validation of a risk predi

SUBMITTER: Heng L 

PROVIDER: S-EPMC12770125 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature