Lower mortality in calcimimetic users compared to non-users in dialysis patients with serum parathyroid hormone levels within the target range.

ABSTRACT: Lower serum parathyroid hormone (PTH) levels are reported to improve mortality and fracture incidence in patients using calcimimetics. We investigated the prognosis of calcimimetic users and non-users with similar PTH levels within the target range. This retrospective study compared 2-year all-cause mortality and the incidence of any fracture in dialysis patients between calcimimetic users (n = 131) and non-users (n = 294) with PTH levels between 60 and 240 pg/mL using a propensity score-matched model. Kaplan-Meier survival curves censored by PTH level, calcimimetic use, and other factors were compared; then, adjusted Cox proportional hazards regression analysis was performed. After matching, mortality was significantly lower in calcimimetic users than in non-users (n = 130; hazard ratio [

SUBMITTER: Okada K 

PROVIDER: S-EPMC12770436 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature