Mechanistic approach to laser-induced oxidative stress and apoptosis in breast cancer cells using BSA-functionalized gold nanoparticles.

ABSTRACT: Photothermal therapy (PTT) using gold nanoparticles (AuNPs) offers a promising platform for targeted cancer treatment due to its minimally invasive nature and potential for spatial precision. However, achieving selective cytotoxicity while preserving healthy tissue remains a critical challenge. In this study, we developed a biocompatible photothermal platform using bovine serum albumin-functionalized gold nanoparticles (AuNPs@BSA) to selectively induce apoptosis in MDA-MB-231 breast cancer cells. The successful synthesis and surface modification of AuNPs were confirmed through UV-Vis spectroscopy, Fourier-transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and zeta potential analysis. The results of FTIR confirmed functionalization of AuNPs by BSA and zeta potential res

SUBMITTER: Salabat A 

PROVIDER: S-EPMC12770464 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature