Glycolysis-related MiRNA signature predicts prognosis, recurrence risk, and therapeutic responses in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a highly heterogeneous malignant tumor characterized by a high recurrence rate and poor prognosis. In recent years, the study of miRNAs as potential prognostic markers and therapeutic targets, as well as their regulation of the glucose metabolism pathway in HCC, has attracted widespread attention. This study aims to construct a risk model for predicting the prognosis of HCC by analyzing differentially expressed glycolysis-related miRNAs and further explore their relationship with the immune microenvironment and drug sensitivity. In this study, the original mRNA and miRNA expression data of HCC were downloaded from the TCGA and GEO databases, respectively, with a total of 374 TCGA samples and 97 GSE30297 samples collected. A prognostic risk score model for

SUBMITTER: Su G 

PROVIDER: S-EPMC12770607 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature