MiRNA expression analysis from circulating exosomes in Barrett's esophagus patients with visceral obesity.

ABSTRACT: Visceral obesity is a recognized risk factor for Barrett's esophagus (BE). Circulating exosomal mirnas have been identified as potential biomarkers of BE. The aim of this study was to elucidate the characteristics of plasma exosomal miRNA expression in BE patients with or without visceral obesity and to explore its potential regulatory mechanisms in the pathogenesis of the disease. From June 1, 2017 to August 31, 2020, healthy people and BE patients were recruited at center and divided into four groups: Barrett's esophagus patients with visceral obesity (VOBE), Barrett's esophagus patients (BE), visceral obese controls (VOC), and healthy controls (HC).Serum samples were collected after approval by the Ethics Committee, exosomes were isolated by ultrafast centrifugation, and the expression

SUBMITTER: Liu M 

PROVIDER: S-EPMC12770631 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature