Probiotic Development Strategy Centered on Stability and Regulatory Considerations.

ABSTRACT: The development of probiotic strains has become a major focus in both academic and industrial research, driven by their health benefits and growing consumer demand. However, functional outcomes demonstrated under laboratory conditions often fail to align with the stability and large-scale performance required for industrial applications, creating a major obstacle to commercialization. This gap underscores the need for standardized evaluation frameworks that integrate scientific validation with industrial performance metrics. This review critically examines the probiotic development pipeline, encompassing strain screening, resilience-enhancing strategies, and global regulatory frameworks. Particular attention is given to the effects of production stressors such as heat, oxygen, and digestio

SUBMITTER: Kim H 

PROVIDER: S-EPMC12770815 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature