A human brain map of mitochondrial respiratory capacity and diversity.

ABSTRACT: Mitochondrial oxidative phosphorylation (OXPHOS) powers brain activity^1,2, and mitochondrial defects are linked to neurodegenerative and neuropsychiatric disorders^3,4. To understand the basis of brain activity and behaviour, there is a need to define the molecular energetic landscape of the brain^5-10. Here, to bridge the scale gap between cognitive neuroscience and cell biology, we developed a physical voxelization approach to partition a frozen human coronal hemisphere section into 703 voxels comparable to neuroimaging resolution (3 × 3 × 3 mm). In each cortical and subcortical brain voxel, we profiled mitochondrial phenotypes, including OXPHOS enzyme activities, mitochondrial DNA and volume density, and mitochondria-specific respiratory capacity. We show

SUBMITTER: Mosharov EV 

PROVIDER: S-EPMC12770858 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature