Efficacy and safety of high-dose hypofractionated palliative radiotherapy (40 Gy in 10 daily fractions) for non-small cell lung cancer.

ABSTRACT:

Purpose

Palliative thoracic radiotherapy plays a crucial role in the management of patients with non-small cell lung cancer (NSCLC). Conventional dose-fractionation schemes often yield modest and short-lived tumor responses. This study aims to evaluate the efficacy and safety of a high-dose hypofractionated radiotherapy regimen of 40 Gy in 10 daily fractions in NSCLC.

Materials and methods

Consecutive NSCLC patients who underwent palliative thoracic radiotherapy using the 40 Gy in 10 daily fractions regimen between January 2017 and December 2022 were identified from institutional databases of two tertiary oncology centers. Treatment responses were assessed using the Response Evaluation Criteria in Solid Tumor criteria. Local tumor control rate was estimated using cumulative

SUBMITTER: Chow JCH 

PROVIDER: S-EPMC12770877 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature