Pathological findings of stereotactic cardiac radiotherapy for the treatment of ventricular tachycardia in patients with Chagas disease: case series.

ABSTRACT:

Background

Stereotactic arrhythmia radiotherapy (STAR) is a novel, non-invasive therapeutic option for managing ventricular tachycardia (VT), including in patients with chronic Chagas cardiomyopathy (CCC). However, the histopathological substrate underlying its antiarrhythmic effect remains poorly defined, particularly in the Chagas population. This study aims to characterize the myocardial tissue changes following STAR in two CCC patients, evaluated at different time points after treatment.

Case summary

Two CCC patients with recurrent VT underwent STAR as part of a multidisciplinary treatment protocol. One patient died 50 days post-STAR, and the other underwent heart transplantation 702 days after the procedure. Myocardial tissue was collected from irradiated and non-irradi

SUBMITTER: Kulchetscki RM 

PROVIDER: S-EPMC12770904 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature