Noninvasive assessment of skin barrier function: evaluating ceramide-based moisturizer using confocal Raman spectroscopy.

ABSTRACT:

Significance

Confocal Raman spectroscopy (CRS) is a noninvasive technique that enables detailed biochemical analysis of the skin, providing insights into its structural and molecular composition. Atopic dermatitis and hand eczema, both characterized by impaired skin barrier function, require effective monitoring tools to assess treatment efficacy.

Aim

We aimed to quantitatively evaluate changes in skin physiological and biochemical parameters following the application of a ceramide-based moisturizer (test cream) compared with an aqueous moisturizer (control cream) in healthy volunteers and eczema patients.

Approach

Skin physiological assessments and CRS measurements were performed to evaluate water content and ceramide levels in both superficial and deeper skin layers

SUBMITTER: Rajarahm P 

PROVIDER: S-EPMC12770911 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature