Topical Heparin in Burns: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.

ABSTRACT: Burns are associated with significant inflammation and pain. Topical agents like heparin can modulate these processes and improve outcomes. Our study aims to evaluate the effectiveness of using topical heparin (TH) in patients with burns. On August 7, 2024, we conducted a literature search on PubMed, Scopus, and Web of Science. Only randomized controlled studies were included. Data were extracted on analgesic drug usage, bleeding events, sepsis, visual analog scale pain scores, length of hospital stay, and mortality. Statistical analysis was performed using R software (version 4.4.1), heterogeneous data. Seven randomized controlled trials (503 patients; topical heparin: 249, control: 254) were included. Analgesic use (1-2 times/day: RR = 3.04, P = .68; 3-4 times/day: RR = 0.06, P = .18), b

SUBMITTER: Nassar M 

PROVIDER: S-EPMC12770970 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature