Plasma cannabinoid concentrations and transference during long-term industrial hemp administration in cattle.

ABSTRACT: With recent legalization of industrial hemp (IH) production and increased interest in including IH and its byproducts in cattle feed, there is a need to establish the pharmacokinetic profiles of cannabinoids in cattle and guidelines for animal surveillance programs to ensure safety of cattle products entering the food supply. Our group has previously described the pharmacokinetics of cannabidiolic acid (CBDA) and concentrations of other cannabinoids in plasma. In the present study, the plasma cannabinoid concentrations in twelve (12) Holstein steers receiving alfalfa pellet placebo (PLBO), chlortetracycline (CTC) pellets (1.1 mg/kg/d), IH (5.5 mg/kg/d CBDA; HEMP), or a combination of CTC and IH (COMBO) once daily for 63 d were evaluated. Plasma samples were collected every 7 d from day -7

SUBMITTER: Fritz BR 

PROVIDER: S-EPMC12770982 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature