Global burden of ischemic heart disease attributable to temperature extremes in adults aged 40 years and older: Trends, inequalities, and projections (1990-2050).

ABSTRACT: Ischemic heart disease (IHD) remains the leading cause of global mortality. Apart from traditional risk factors like hypertension and dyslipidemia, ambient temperature extremes-both cold and heat-have increasingly been recognized as important but underexplored contributors to IHD burden, with the impact of climate change necessitating a deeper understanding of temperature-related cardiovascular risks. Here we performed a cross-sectional analysis of Global Burden of Disease 2021 data stratified by region, sex, age, and Socio-Demographic Index (SDI) aiming to demonstrating the burden of temperature extremes-related IHD. Temporal trends were quantified using estimated annual percentage change (EAPC), inequalities were assessed via the slope index and concentration index, and autoregressive in

SUBMITTER: Zuo Z 

PROVIDER: S-EPMC12771079 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature