Tumor-Targeting T₁ MRI Contrast Agents with Antioxidant Effects: Gadolinium Oxide Nanoparticles Grafted with Polydopamine- and Polyserotonin-Conjugated Polyacrylic Acids.

ABSTRACT: Polydopamine (pdop) and polyserotonin (pser) can target tumor cells through their conjugation with dopamine (dop)- and serotonin (ser)-receptors overexpressed on tumor cells. In this study, pdop- or pser-conjugated poly-(acrylic acid) (PAA)-grafted gadolinium oxide nanoparticles (denoted as pdop-PAA-Gd₂O₃ and pser-PAA-Gd₂O₃ NPs) were synthesized for the first time via polymerization of dop and ser during their conjugation with the PAA component of PAA-Gd₂O₃ NPs; then, the obtained pdop-PAA-Gd₂O₃ and pser-PAA-Gd₂O₃ NPs were applied as tumor-targeting positive (T₁) magnetic resonance imaging (MRI) contrast agents. In addition, their antioxidant effects were investigated by

SUBMITTER: Liu Y 

PROVIDER: S-EPMC12771183 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature