Analysis of the therapeutic effect of allogeneic hematopoietic stem cell transplantation in the treatment of pediatric acute lymphoblastic leukemia with <i>E2A::HLF</i> fusion gene: a case series.

ABSTRACT:

Background

The fusion gene E2A::HLF (TCF3::HLF) is present in <1% of B-cell acute lymphoblastic leukemia (ALL) patients, mainly in older children and adolescents. Patients with E2A::HLF fusion B-ALL consistently have dismal outcomes, even after hematopoietic stem cell transplantation (HSCT). Chimeric antigen receptor T-cell (CAR-T) therapy and donor lymphocyte infusion (DLI) applied in this kind of disease have rarely been reported. In this case series, we will focus on the safety and effectiveness of CAR-T and DLI treatments. This may refine therapeutic strategies and improve survival for this high-risk subgroup.

Case description

In this case series, we review the clinical course of 4 pediatric patients with E2A::HLF fusion B-ALL. All four patien

SUBMITTER: Jing Y 

PROVIDER: S-EPMC12771198 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature